Congratulations Jodi (Hallgren) and Lauren (Netzel) on your first publication!
Simeone, K. A.,Hallgren, J., Bockman, C. S., Aggarwal, A., Kansal, V., Netzel, L., Iyer, S. H., Matthews, S. A., Deodhar, M., Oldenburg, P. J., Abel, P. W., Simeone, T. A. (2018). Respiratory dysfunction progresses with age in Kcna1-null mice, a model of sudden unexpected death in epilepsy. Epilepsia, 59(2), 345-357.
Congratulations Shruthi on your second publication!
Iyer, S. H., Matthews, S. A., Simeone, T. A., Maganti, R., Simeone, K.A. (2018). Accumulation of rest deficiency precedes sudden death of epileptic Kv1.1 knockout mice, a model of sudden unexpected death in epilepsy. Epilepsia, 59(1), 92-105.
Congratulations Ted on your first, first-author publication as a postdoctoral fellow in our lab!
Warren TJ, Simeone TA, David Smith D, Grove R, Adamec J, Samson KK, Roundtree HM, Madhavan D, Simeone KA. Adenosine has two faces: Regionally dichotomous adenosine tone in a model of epilepsy with comorbid sleep disorders. Neurobiology of Disease. 2018 Jan 30. doi: 10.1016/j.nbd.2018.01.017.
Congratulations Lauren on your oral presentation of your undergraduate research!
'Respiratory dysfunction worsens as seizure threshold decreases in Kv1.1 knockout mice'. Midwest Student Biomedical Research Forum.
Congratulations Malavika on your oral presentation of your graduate research!
'Pharmacologically untangling sleep disorders and seizures'. Midwest Student Biomedical Research Forum.
2017
American Epilepsy Society Meeting 2017: Fantastic poster presentations by Ted and Shruthi!
Warren TJ, Samson KK, Roundtree HR, Simeone TA, Simeone KA. (2017). Differences in adenosine tone and inhibition in the hypothalamus and hippocampus of Kcna1 KO mice. American Epilepsy Society, Washington, D.C. Poster presentation.
Gavrilovici C, Simeone TA, Warren TJ, & Rho JM.Hippocampal interneuron dysfunction in the Kcna1-null mouse model of epilepsy. American Epilepsy Society, Washington, D.C. Poster presentation.
Iyer, S. H., Matthews, S. A., Simeone, T. A., Maganti, R., Simeone, K. A. (2017). Disrupted rest-active rhythm precedes sudden death in epilepsy in Kv1.1 knockout mouse model. American Epilepsy Society, Washington, D.C. Poster presentation.
Congratulations Sara Knowles!
On your Neuroscience degree from Creighton and beginning your Neuroscience graduate career at Arizona State University.
Congratulations Sarah Budney!
On being one of the selected medical students to finish training at the Creighton campus at St. Joseph's Hospital in Phoenix, AZ.
It's been a busy year! Great work everyone:
Simeone TA, Matthews SA, Samson KK, Simeone KA. (2017) Regulation of brain PPARgamma contributes to ketogenic diet anti-seizure efficacy Exp Neurol. 287:54-64.
Singh-Taylor A, Molet J, Jiang S, Korosi A, Bolton JL, Noam Y, Simeone K, Cope J, Chen Y, Mortazavi A, Baram TZ. NRSF-dependent epigenetic mechanisms contribute to programming of stress-sensitive neurons by neonatal experience, promoting resilience. Mol Psychiatry. 2017 Jan 10. doi: 10.1038/mp.2016.240. [Epub ahead of print]
Simeone TA, Simeone KA, Rho JM. (2017) Ketone Bodies as Anti-Seizure Agents. Neurochem Res.; 42:2011-2018.
Kerrigan JF, Parsons A, Tsang C, Simeone K, Coons S, Wu J. (2017) Hypothalamic hamartoma: Neuropathology and epileptogenesis. Epilepsia.2:22-31.
Simeone TA, Matthews SA, Simeone KA. (2017) Synergistic protection against acute flurothyl-induced seizures by adjuvant treatment of the ketogenic diet with the type 2 diabetes drug pioglitazone. Epilepsia. Aug;58:1440-1450.
Omaha Epilepsy Walk 2017!
2016
Congratulations everyone on the longevity paper - Thank you for all of your hard work!
Simeone, K. A., Matthews, S. A., Rho, J. M. and Simeone, T. A. (2016), Ketogenic diet treatment increases longevity in Kcna1-null mice, a model of sudden unexpected death in epilepsy. Epilepsia, 57, e178–e182.
Congratulations Shruthi on your oral presentations!
Iyer, S. H., Matthews, S. A., Simeone, T. A., Simeone, K. A. (2016) Progressive worsening of sleep disruption as a novel biomarker for sudden unexpected death in epilepsy (SUDEP) in Kv1.1KO mice. Midwest Student Biomedical Research Forum, Omaha, Platform Presentation.
Iyer, S. H., Aggarwal A, Matthews, S. A., Simeone, T. A., Simeone, K. A. (2016) Does progressive elevation in orexinergic activity promote bradycardia in Kv1.1 KO mice, a model of SUDEP? American Epilepsy Society, Houston, Poster presentation.
Congratulations Harrison on publishing your PhD thesis work!
Roundtree, H. M., Simeone, T. A., Johnson, C., Matthews, S. A., Samson, K. K., & Simeone, K. A. (2016). Orexin Receptor Antagonism Improves Sleep and Reduces Seizures in Kcna1-null Mice. Sleep, 39(2), 357–368.
Congratulations Brianna Zieba!
On your bachelor's degree from Creighton and beginning your graduate career in the Genetics Counseling Graduate Program in Colorado!
American Epilepsy Society 2016: Congratulations Shruthi on your poster presentation!
Chair Basic Research Highlights Session for the 5th Global Symposium on Ketogenic Therapies, Banff, Alberta Canada
Invited speaker: ‘Ketogenic Diet and Comorbidities in Epilepsy,’ 5th Global Symposium on Ketogenic Therapies, Banff, Alberta Canada
Funding:
Awarded Citizens United for Research in Epilepsy. 'Orexin triggers autonomic destabilization in SUDEP' 2016-2018. Role: PI
Awarded Nebraska LB 692 New Initiatives Research Grant. 'Progressive cardiovascular instability in a model of SUDEP. 2016-2017. Role: PI
2015
Kim DY*, Simeone KA*, Simeone TA, Pandya J, Wilke J, Ahn Y, Geddes J, Sullivan PG, Rho JM (2015). Ketone Bodies Mediate Anti-Seizure Effects Through mPT. Ann of Neurol. 78:77-87.
American Epilepsy Society 2015: Congratulations Shruthi on sharing your research and being selected for the Press Highlight!
Iyer, S. H., Roundtree, H. M., Knowles S, Simeone, K. A. (2015) Ontogeny of sleep disruption and orexin levels correspond with epilepsy onset and progression in Kv1.1KO mice. American Epilepsy Society, Philadelphia, Press Highlights and Poster presentation.
Congratulations Shruthi on your first oral presentation as a masters student and travel award!
Iyer, S. H., Matthews, S. A., Samson, K.K, Simeone, K. A, Simeone, T. A. (2015) Anti-seizure effects of ketogenic diet are mediated via regulation of brain PPARγ, a nutritionally responsive transcription factor. Anticonvulsant Drug Development Symposium, University of Utah, Platform presentation and travel award.
Invited speaker: ‘A tale of two tales: mitochondria and the ketogenic diet,’ Creighton University School of Medicine (CUSOM),
Invited speaker: ‘Mitochondria as a Novel Anti-Seizure Target,’ CUSOM, Omaha, NE.
Congratulations Harrison on earning your PhD!
2014
Way to go team!
Simeone, T. A., Samson, K. K., Matthews, S. A., and Simeone, K. A. (2014). In vivo ketogenic diet treatment attenuates pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices from epileptic Kv1.1a knockout mice. Epilepsia. 55.
Simeone, K. A., Matthews, S. A., Samson, K. K., and Simeone, T. A. (2014). Targeting deficiencies in mitochondrial respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy and in a model of acute temporal lobe seizures. Experimental Neurology, 251, 84–90.
Funding:
Awarded National Institutes of Health, NINDS R01 (NS085389) 'PPARgamma, Epilepsy and Therapeutics.' 2014-2019. Role: Co-I
2013
Simeone TA, Simeone KA, Samson KK, Kim DY, Rho JM (2013). Loss of the Kv1.1 potassium channel promotes pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices. Neurobio Dis. 54:68-8.
Travel Award for 'Curing the Epilepsies 2013: Pathways Forward Conference' sponsored by NIH NINDS in Bethesda, MD.
2012
Young Investigator Faculty Member Award, Creighton University School of Medicine
Excellence in Research Award, Creighton University School of Medicine
Awarded National Institute of Health NINDS (NS072179) 'Adenosine, Hypocretin and Sleep disorder co-morbidities Associated Epilepsy' 2012-2018. Role: PI
2011
Simeone KA, Kim DY, Kerrigan JF, Rho JM, Simeone TA (2011). L-type calcium channel blockade reduces network activity in human epileptic hypothalamic hamartoma tissue. Epilepsia 52:531-540.
Funding:
Awarded Health Future Foundation Faculty Start-up Funds. 2011-2014
2010
Nominated and selected for the AAMC Early Career Women Faculty Professional Development Seminar, Washington DC.
Invited speaker: ‘Epilepsy, Sleep Disorders and Adenosine,’ William C. Dement Sleep and Chronobiology Summer Research Apprenticeship Program Brown University, Providence, RI
Fenoglio-Simeone KA*, Chan M*, Muhammad L, Seminara S, Kerrigan JF. (2010) Precocious Puberty Associated with Hypothalamic Hamartomas Correlates with Anatomic Features but not with Expression of GnRH, TGFα, or KISS1. Horm Res Paediatr.73:312-9.
Funding:
Awarded Nebraska LB 692 New Initiatives Research Grant 'A Novel Mitochondria-Targeted Treatment to Prevent Epilepsy and its Pathology. 2010-2011. Role: PI
Epilepsy Foundation of America Grant 'Mitochondrial Impairment During Epileptogenesis'. 2010-2011. Role: PI
2009 - Opened the laboratory!
Fenoglio-Simeone KA, Wilke JC, Milligan HL, Allen C, Rho JM, Maganti R (2009). Ketogenic diet treatment abolishes seizure periodicity and improves diurnal rhythmicity in epileptic Kcna1-null mice. Epilepsia 50:2027-34.
Fenoglio-Simeone KA*, Mazarati A*, Hockley S, Shin D, Wilke J, Milligan H, Sankar R, Rho J, Maganti R (2009). Effects of the Selective Melatonin Receptor Agonist Ramelteon. Epilepsy and Behav. 16:52-7.
Kim DY, Fenoglio KA, Kerrigan JF, Rho JM (2009). Bicarbonate contributes to GABA(A) receptor-mediated neuronal excitation in surgically resected human hypothalamic hamartomas. Epilepsy Res. 83:89-93.
Head E, Nukala VN, Fenoglio-Simeone KA, Muggenburg BA, Cotman CW, Sullivan PG (2009). Effects of age, dietary and behavioral enrichments on brain mitochondria in a canine model of human aging. Exp Neurol. 220:171-6.
Funding:
Awarded the Health Future Foundation Grant 'The Role of Hypocretin in the Sleep Disorders of Epilepsy' 2009-2011. Role: PI